Unlike other countries, engineers have increased their relevance and market demand in recent decades in Chilean society. Engineering programs attract and enroll the best students from high schools and engineers rank in the top salary range.This success has its origins in different historical and contextual elements.In 1986, as a result of what ended up being an anticipation of current tendencies, within the industrial engineering program a new improvement process was initiated based on the incorporation of Biology of Cognition and Radical Constructivism proposals. This process, called the Learning to Start Starting by Learning (LSSL) Program, has resulted in the design and implementation of new courses, workshops, and other learning activities, all based on relating entrepreneurship skills development with the enhancement of learning capabilities.This paper is aimed at sharing the main elements and results of this innovative program in engineering education.