This paper presents the project-based innovation and entrepreneurship education activities of the Mercer Entrepreneurship Engineering Education Program (MEEEP), developed and implemented through Kern Family Foundation grants. How the Mercer University School of Engineering (MUSE) promotes an entrepreneurial mindset among engineering students is presented in terms of curriculum development, entrepreneurship club activities, recruiting and involving students and faculty, assessment of entrepreneurship courses, and the challenges encountered in implementing/sustaining the program. The course sequence integrates elements of entrepreneurship with engineering; develops an entrepreneurial mindset in engineering students; fosters innovation and creativity in engineering disciplines; and helps students to develop business plans for entrepreneurial design projects. The expansion of this program through the recently established Center for Innovation and Entrepreneurship (CIE) will support educational interdisciplinary curricula and co-curricular activities directly benefiting students and provide multi- and cross-disciplinary teaching, learning, and research opportunities on innovation and entrepreneurship to faculty and students.